Anti-Mouse CD3e FITC

11-0030-85

500ug

USA

The eBioG4.18 monoclonal antibody recognizes the rat CD3 protein. CD3 is a

critical component of the T-cell receptor (TCR) and is a marker of the
T-cell lineage. CD3 is a complex of several subunits and, upon bindingof a
TCR ligand, participates in transduction of signals from the TCR to the nucleus
which results in a variety of cellular responses includingtranscription of
IL-2 and clonal expansion. in vitro, immobilized G4.18 monoclonal antibody has
been demonstrated to activate T cells, while soluble G4.18 inhibited allogeneic
mixed-lymphocyte proliferative responses and cell-mediated cytotoxicity to
allogeneic target cells. in vivo, G4.18 was demonstrated to induce long-term
specific tolerance to an organ allograft.