Anti-Mouse CD3e FITC

11-0031-85
500ug

USA

The 145-2C11 monoclonal antibody reacts with mouse CD3e, a 20 kDa subunit

of the TCR complex. Along with the other CD3 subunits, gamma and delta,
the epsilon chain is required for proper assembly, trafficking and surface
expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally
regulated manner and by all mature T cells. Binding of 145-2C11 to TCR initiates
the intracellular biochemical pathway resulting in cellular activation,
proliferation, and apoptosis depending on specific conditions utilized.
145-2C11 is commonly used as a phenotypic marker for mouse T cells.