Anti-Rat CD3 FITC

11-0030-82
100ug

USA

The eBioG4.18 monoclonal antibody recognizes the rat CD3 protein.

CD3 is a critical component of the T-cell receptor (TCR) and is a
marker of the T-cell lineage. CD3 is a complex of several subunits
and, upon binding of a TCR ligand, participates in transduction of
signals from the TCR to the nucleus which results in a variety of
cellular responses including transcription of IL-2 and clonal expansion.
in vitro, immobilized G4.18 monoclonal antibody has been demonstrated to
activate T cells, while soluble G4.18 inhibited allogeneic mixed-lymphocyte
proliferative responses and cell-mediated cytotoxicity to allogeneic target
cells. in vivo, G4.18 was demonstrated to induce long-term specific tolerance to anorgan allograft.