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Murine NOGGIN
货 号：250-38
产品规格：5ug
原 产 地：USA
参考价格：960 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Murine NOGGIN 250-38
描述:
Noggin
belongs to a group of diffusible proteins which bind to ligands of the
TGF-β family and regulate their activity by inhibiting their access to
signaling receptors. The interplay between TGF-β ligands and their
natural antagonists has major biological significance during development
processes, in which cellular response can vary considerably depending
upon the local concentration of the signaling molecule. Noggin was
originally identified as a BMP-4 antagonist whose action is critical for
proper formation of the head and other dorsal structures.
Consequently, Noggin has been shown to modulate the activities of other
BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in
mice results in prenatal death and recessive phenotype displaying a
severely malformed skeletal system. Conversely, transgenic mice
over-expressing Noggin in mature osteoblasts display impaired
osteoblastic differentiation, reduced bone formation, and severe
osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked
homodimer consisting of two 206 amino acid polypeptide chains.
氨基酸序列:
MQHYLHIRPA
PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG
GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP
VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG
WIPIQYPIIS ECKCSC
来源:
E.coli
纯度:
Greater than 95% by SDS-PAGE gel and HPLC analyses.