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Human BDNF人BDNF
货 号：450-02
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human BDNF人BDNF 450-02
别名:
Brain Derived Neurotrophic Factor, Abrineurin
描述:
BDNF
is a member of the NGF family of neurotrophic growth factors. Like
other members of this family, BDNF supports neuron proliferation and
survival. BDNF can bind to a low affinity cell surface receptor called
LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4.
However, BDNF mediates its neurotrophic properties by signaling through
a high affinity cell surface receptor called gp145/trkB. BDNF is
expressed as the C-terminal portion of a 247 amino acid polypeptide
precursor, which also contains a signal sequence of 18 amino acid
residues and a propeptide of 110 amino acid residues. Recombinant Human
BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by
strong non-covalent interactions. Human and Mouse BDNF sequences are
identical.
氨基酸序列:
MHSDPARRGE
LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR
GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.