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Human Activin A
货 号：120-14
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human Activin A 120-14
别名:
Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
描述:
Activin
A is a TGF-β family member that exhibits a wide range of biological
activities, including regulation of cellular proliferation and
differentiation, and promotion of neuronal survival. Elevated levels of
Activin A in human colorectal tumors and in postmenopausal women have
been implicated in colorectal and breast cancers, respectively. The
biological activities of Activin A can be neutralized by inhibins and by
the diffusible TGF-β antagonist, follistatin. Activin A binds to the
two forms of activin receptor type I (Act RI-A and Act RI-B) and two
forms of activin receptor type II (Act RII-A and Act RII-B). Activins
are homodimers or heterodimers of different β subunits. They are
produced as precursor proteins with an amino terminal propeptide that is
cleaved to release the C-terminal bioactive ligand. Human/Murine/Rat
Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains,
each containing 116 amino acid residues.
氨基酸序列:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
来源:
(BTI‐Tn‐5B1‐4) Hi‐5 Insect cells*
纯度:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by its ability to inhibit the proliferation of murine
MPC-11 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x
105 units/mg.