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Human TGF-beta1人TGFβ1
货 号：100-21
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human TGF-beta1人TGFβ1 100-21
别名:
Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor
描述:
The
three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the
same receptor and elicit similar biological responses. They are
multifunctional cytokines that regulate cell proliferation, growth,
differentiation and motility as well as synthesis and deposition of the
extracellular matrix. They are involved in various physiological
processes including embryogenesis, tissue remodeling and wound healing.
They are secreted predominantly as latent complexes which are stored at
the cell surface and in the extracellular matrix. The release of
biologically active TGF-β isoform from a latent complex involves
proteolytic processing of the complex and /or induction of
conformational changes by proteins such as thrombospondin-1. TGF-β1 is
the most abundant isoform secreted by almost every cell type. It was
originally identified for its ability to induce phenotypic
transformation of fibroblasts and recently it has been implicated in the
formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each
subunit containing 112 amino acid residues, linked by a single
disulfide bond.
氨基酸序列:
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
来源:
HEK293 cells
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 was determined by TGF-beta1's ability to inhibit the mouse
IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml,
corresponding to a specific activity of ≥ 2 x 107 units/mg.