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Human IFN-γ人IFNγ
货 号：300-02
产品规格：20ug
原 产 地：USA
参考价格：960 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human IFN-γ人IFNγ 300-02
别名:
Immune Interferon, type II interferon, T cell interferon, MAF
描述:
IFN-γ
is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as
well as activated NK cells. IFN-γ receptors are present in most immune
cells, which respond to IFN-γ signaling by increasing the surface
expression of class I MHC proteins. This promotes the presentation of
antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting
cells and antigen-recognizing B and T lymphocytes regulate the
antigen-specific phases of the immune response. Additionally, IFN-γ
stimulates a number of lymphoid cell functions including the
anti-microbial and anti-tumor responses of macrophages, NK cells, and
neutrophils. Human IFN-γ species-specific and is biologically active
only in human and primate cells. Recombinant human IFN-γ is a 16.8 kDa
protein containing 144 amino acid residues.
氨基酸序列:
MQDPYVKEAE
NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS
VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR
KRSQMLFQGR RASQ
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Assay #1: Determined by its ability to induce apoptosis in HeLa cells. The expected ED50 for this effect is 5.0-10.0 ng/ml.
Assay #2: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Assay #2: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.