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Human TNF-alpha人TNFα
货 号：300-01A
产品规格：10ug
原 产 地：USA
参考价格：960 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human TNF-alpha人TNFα 300-01A
别名:
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
描述:
TNF-α
is a pleiotropic pro-inflammatory cytokine secreted by various cells
including adipocytes, activated monocytes, macrophages, B cells, T cells
and fibroblasts. It belongs to the TNF family of ligands and signals
through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide
variety of tumor cells and is an essential factor in mediating the
immune response against bacterial infections. TNF-α also plays a role
in the induction of septic shock, auto immune diseases, rheumatoid
arthritis, inflammation, and diabetes. Recombinant human TNF-α is a
soluble 157 amino acid protein (17.4 kDa) which corresponds to
C-terminal extracellular domain of the full length transmembrane
protein.
氨基酸序列:
VRSSSRTPSD
KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP
STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD
RLSAEINRPD YLDFAESGQV YFGIIAL
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the cytolysis of murine L929 cells in the presence of
Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥
2 x 107 units/mg.