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Murine IL-6小鼠白介素6
货 号：216-16
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Murine IL-6小鼠白介素6 216-16
别名:
26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
描述:
IL-6
is a pleiotropic cytokine that plays an important role in host defense
by regulating immune and inflammatory responses. Produced by T cells,
monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has
diverse biological functions. It stimulates B-cell differentiation and
antibody production, synergizes with IL-3 in megakaryocyte development
and platelet production, induces expression of hepatic acute-phase
proteins, and regulates bone metabolism. IL-6 signals through the IL-6
receptor system that consists of two chains, IL-6R α and gp130. Murine
IL-6 is inactive on human cells, while both human and murine are equally
active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein
containing 188 amino acid residues.
氨基酸序列:
MFPTSQVRRG
DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI
QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF
NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of the proliferation of
IL-6-dependent murine 7TD1 cells is ≤ 0.02 ng/ml, corresponding to a
specific activity of ≥ 5 x 107 units/mg.