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Human IL-4人白介素4
货 号：200-04
产品规格：5ug
原 产 地：USA
参考价格：960 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human IL-4人白介素4 200-04
别名:
BCGF, BCDF, B cell stimulating factor (BSF-1)
描述:
IL-4
is a pleiotropic cytokine that regulates diverse T and B cell responses
including cell proliferation, survival and gene expression. Produced
by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the
differentiation of naive CD4+ T cells into helper Th2 cells,
characterized by their cytokine-secretion profile that includes
secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral
immune response. Another dominant function of IL-4 is the regulation of
immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive
IL-4 production by Th2 cells has been associated with elevated IgE
production and allergy. Recombinant human IL-4 is a 15.1 kDa globular
protein containing 130 amino acid residues.
氨基酸序列:
MHKCDITLQE
IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT
AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤
0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.