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Murine IL-1alpha小鼠白介素1α
货 号：211-11A
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Murine IL-1alpha小鼠白介素1α 211-11A
别名:
Hematopoietin-1,
Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte
Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
描述:
IL-1α
is a non-secreted proinflammatory cytokine produced in a variety of
cells including monocytes, tissue macrophages, keratinocytes and other
epithelial cells. Both IL-1α and IL-1β binds to the same receptor and
has similar if not identical biological properties. These cytokines
have a broad range of activities including, stimulation of thymocyte
proliferation, by inducing IL-2 release, B-cell maturation and
proliferation, mitogenic FGF-like activity and the ability to stimulate
the release of prostaglandin and collagenase from synovial cells.
However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a
cell-associated cytokine. Recombinant murine IL-1α is an 17.9 kDa
protein containing 156 amino acid residues.
氨基酸序列:
SAPYTYQSDL
RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP
VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE
LFIATKEQSR VHLARGLPSM TDFQIS
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is
< 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.