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Human IL-1beta人白介素1β
货 号：200-01B
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human IL-1beta人白介素1β 200-01B
产品编号:
200-01B
别名:
Catabolin,
Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte
Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
描述:
IL-1β
is a proinflammatory cytokine produced in a variety of cells including
monocytes, tissue macrophages, keratinocytes and other epithelial cells.
Both IL-1α and IL-1β binds to the same receptor and has similar if not
identical biological properties. These cytokines have a broad range of
activities including, stimulation of thymocyte proliferation, by
inducing IL-2 release, B-cell maturation and proliferation, mitogenic
FGF-like activity and the ability to stimulate the release of
prostaglandin and collagenase from synovial cells. However, whereas
IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated
cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153
amino acid residues.
氨基酸序列:
APVRSLNCTL
RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS
CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM
PVFLGGTKGG QDITDFTMQF VSS
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by
murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity
of ≥ 1 x 109 units/mg.