Anti-Mouse CD8a FITC

11-0081-81

50ug

USA

The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule.

CD8a is an approximately 32-34 kDa cell surface receptor expressedeither as a
heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer(CD8 alpha alpha).
A majority of thymocytes and a subpopulation of mature alpha beta TCR Tcells express CD8
alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial
lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8binds to MHC class I
and through its association with protein tyrosine kinase p56lck plays arole in T cell
development and activation of mature T cells.