Anti-Mouse CD8a FITC

11-0081-85
500ug

USA

The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a

is an approximately 32-34 kDa cell surface receptor expressed either as a
heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer(CD8 alpha alpha).
A majority of thymocytes and a subpopulation of mature alpha beta TCR Tcells express CD8
alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial
lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8binds to MHC class
I and through its association with protein tyrosine kinase p56lck playsa role in T
cell development and activation of mature T cells.