Anti-Mouse CD9 FITC

11-0091-81
50ug

USA

The eBioKMC8 monoclonal antibody reacts with mouse CD9, a 24 kDa memberof the

transmembrane 4 superfamily. This family is characterized by thepresence of four
hydrophobic domains spanning the cell membrane and short N- andC-terminal cytoplasmic
domains. CD9 is expressed by several cell types including monocytes,macrophages, platelets,
early B cells, activated B and T cells, dendritic cells, eosinophils,basophils, endothelial
cells, myoblasts and neuroblasts. On T cells, CD9 functions as aco-stimulatory molecule
on naïve T cells. Furthermore, CD9 is expressed in oocytes, andCD9-deficiency results
in sterility caused by defective gamete fusion. In mouse macrophages,CD9 functionally
associates with FcγRs to modify signals for phagocytosis andinflammatory responses.
In mouse B cells, it was discovered that CD9 is a marker for marginalzone B cells,
B1 cells, and plasma cells. In dendritic cells, recently it wasdemonstrated that CD9
facilitates the association of heterologous MHC II molecules. The levelof CD9 expression
is subject to donor variability.