Anti-Human CD9 FITC

11-0098-41

25tests

USA

The eBioSN4 monoclonal antibody reacts with human CD9. CD9 is a 24 kDamember of

the tetraspanin family, whose members are characterized by the presenceof 4
hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils,
basophils, pre-B cells, activated T cells and neural cell lines.Furthermore, CD9
expression has been associated with a malignant phenotype, includingexpression on 90%
of non T cell acute lymphoblastic leukemia cells and on 50% of chroniclymphocytic and
acute myeloblastic leukemias. In platelets, CD9 is expressed inα-granules and through
association with the integrin αIIb/βIII plays a role in plateletaggregation, as
demonstrated by the use of anti-human CD9 antibodies. CD9 has also beenshown to induce
the aggregation of pre-B cell lines, and the adhesion and migration ofpre-B cells and
Schwann cells. Additionally, it has been demonstrated that CD9 is ableto provide a
co-stimulatory signal for T cells independently of CD28, in the absenceof antigen-presenting
cells. Binding of the eBioSN4 monoclonal antibody partiallycross-blocks binding of another
anti-human CD9 monoclonal antibody, MM2/57.