Anti-Mouse CD11b FITC

11-0112-41
25tests

USA

The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDaintegrin α_M.

CD11b non-covalently associates with CD18 to form α_Mβ₂ integrin (Mac-1) and binds to
CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed by macrophages,NK cells, granulocytes,
activated lymphocytes and mouse B-1 cells in the peritoneal cavity.M1/70 is also cross-reactive
to human CD11b, and can be used for the detection of this antigen onhuman peripheral blood
monocytes, granulocytes, and a subset of NK cells. Through interactionswith its ligands,
CD11b participates in adhesive cell interactions.