Anti-Mouse CD11b FITC

11-0112-85

500ug

USA

The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDaintegrin α_M.

CD11b non-covalently associates with CD18 to form α_Mβ₂ integrin (Mac-1) and binds
to CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed bymacrophages, NK cells,
granulocytes, activated lymphocytes and mouse B-1 cells in theperitoneal cavity. M1/70
is also cross-reactive to human CD11b, and can be used for thedetection of this antigen
on human peripheral blood monocytes, granulocytes, and a subset of NKcells. Through
interactions with its ligands, CD11b participates in adhesive cell interactions.