Anti-Human CD16 FITC

11-0168-41

25tests

USA

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), thelow-affinity receptor

for IgG with an apparent molecular weight of 50-80 kDa. CD16 isrepresented by two
similar genes, CD16A (Fc gammaRIIIA), which exists as ahetero-oligomeric polypeptide-anchored
form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which existas a monomeric
GPI-anchored form in neutrophils. Furthermore, there are two knownpolymorphisms of CD16B,
NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocyticcapacity compared
with NA-1. CD16 binds IgG in the form of immune complexes and showspreferential binding
of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. UponIgG binding,
both CD16 isoforms initiate signal transduction cascades that lead to avariety of
responses including antibody-dependent cell-mediated cytotoxicity(ADCC), phagocytosis,
degranulation and proliferation.