Anti-Canine CD25 FITC

11-0250-41

25tests

USA

This P4A10 monoclonal antibody reacts with canine CD25, the 55-kDainterleukin-2 receptor

alpha (IL-2R\alpha) chain. As in humans and mice, CD25 in dogs isexpressed by early T and B
lineage progenitors as well as by activated mature T and B lymphocytes.CD25 associates with
the IL-2R beta (CD122) and gamma (CD132) chains to form thehigh-affinity IL-2 receptor. On
its own, CD25 binds IL-2 with low affinity. Along with CD4 and Foxp3,CD25 is a major marker
used to define regulatory T cells.

The P4A10 antibody has been reported to recognize the same epitope asthe anti-human CD25
monoclonal antibody ACT-1, but with greater affinity.