Anti-Mouse Siglec H FITC

11-0333-82
100ug
USA

The monoclonal antibody eBio440c recognizes Siglec-H, a proteinexclusively found on

pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC)in the naïve mouse.
Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, andare quick to respond
to viruses. Siglec-H is a transmembrane protein of the Ig superfamilythat like CD33 have
been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM
domain (immunoreceptor tyrosine based inhibitory motif). To overcomethe lack of a
cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing forsignal transduction.

The eBio440c antibody has been shown to inhibit pDC function (inhbitsIFNalpha secretion
in response to CpG).

It has been observed that some mouse strains (such as SJL) have higherpercentages of pDCs
compared to C57BL/6.