Anti-Mouse CD34 FITC

11-0341-81
50ug
USA

The RAM34 monoclonal antibody reacts with mouse CD34, also known as mucosialin.

It has been reported that the RAM34 antibody can be used to detectCD34+Sca-1+c-Kit+ cells.
CD34 is a highly glycosylated (approximately 90-120 kDa) member of thesialomucin family and is
expressed by capillary endothelial cells, bone marrow stroma, and asmall subpopulation of
mouse bone marrow cells. RAM34 has been used to purify mousehematopoietic stem cells (HSC)
to near homogeneity. CD34 expressed on endothelial cells is a ligandfor CD62L and plays a
role in adhesion. Simultaneous staining of mouse bone marrow cells witha cocktail of antibodies
to lineage markers (CD3, CD11b, Ly6G, TER-119 and CD45R/B220) reveals asubset of cells that
stain with the RAM34 antibody and express undetectable to low levels ofthe indicated lineage markers.