Anti-Human CD34 FITC

11-0349-41

25tests
USA

The 4H11 monoclonal antibody reacts with human CD34, also known asmucosialin. CD34 belongs

to a protein family which also includes endoglycan and podocalyxin.Members of this family
are single pass transmembrane proteins with a heavily glycosylatedextracellular and N-terminal
mucin domain. CD34 was first identified as an antigen expressed onhematopoietic progenitors,
and has since been extensively used as a marker to isolate cellscapable of hematopoietic cell
engraftment. In spite of this, the function of CD34 remains unresolved.In addition to expression
on hematopoietic progenitors, CD34 is expressed on some populations ofmesenchymal stem cells,
tumor cell lines, and by vascular endothelia in the adult. Epitopes ofCD34 have been assigned to
three classes (class I, II or III) based on their differentialsensitivity to enzymatic cleavage
by neuraminidase, chymopapain, or O-glycoprotease. According to thisanalysis, the 4H11 antibody
belongs to class III, indicating that it reacts with a protein epitope.