Anti-Human/Non-Human Primate CD35 FITC

11-0359-41

25tests
USA

This E11 monoclonal antibody reacts with human and non-human primateCD35, which is also known

as complement receptor 1 (CR1). CD35 is expressed on B cells, T cellsubsets, follicular dendritic
cells, macrophages, neutrophils, eosinophils, and erythrocytes. Thiscell surface protein is also
present on non-immune cells such as glomerular podocytes and Langerhanscells. CD35 binds the
complement components C3b and C4b, which are derived from cleavage ofC3 and C4, respectively,
in the classical and alternative complement pathways. In humans, CD35has been implicated in
a variety of roles, including complement activation, transporting C3complexes on erythrocytes,
phagocytosis of complement-bound neutrophils and macrophages, B cellproliferation, and opsonization.
Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host
erythrocytes by binding CD35. Decreased expression of CD35 onerythrocytes has been associated
with systemic lupus erythematosus (SLE), type I diabetes, andrheumatoid arthritis.

The E11 antibody has been reported to crossreact to capuchin monkey,chimpanzee, cynomologus
monkey, olive baboon, and rhesus macaque.