Anti-Human CD36 FITC

11-0369-41

25tests
USA

The monoclonal antibody eBioNL07 recognizes human CD36, which is amember of the class

B scavenger receptor family. CD36 was originally identified as a platelet-membrane
lycoprotein also called glycoprotein IV and a receptor forthrombospondin-1 (TSP-1) and
extracellular matrix proteins. Binding to TSP-1 is in the CLESH (CD36LIMP-II Emp sequence homology)
domain of CD36. CD36 expression is broad and includes microvascular(but not large vessel)
endothelium, adipocytes, skeletal muscle, dendritic cells, epithelia ofthe retina, breast,
and intestine, smooth muscle cells, and hematopoietic cells, includingerythroid precursors,
platelets, monocytes/macrophages, DCs and megakaryocytes. Expression onplatelets is absent
on Nak-a negative donors. Unlike other scavenger receptor, CD36 bindsLDL that has been
exposed to “minimally” oxidizing conditions. CD36 is also a fatty acidtranslocase (FAT) necessary
for the transport of long-chain fatty acids (LCFAs) and therefore mayplay a role in atherosclerosis.