Brefeldin A (ab120299)  ab120299  abcam

    Product nameBrefeldin A
    Description
    Inhibitor of ADP-ribosylation factor
    Alternative names
        Ascotoxin
        BFA
        Cyanein
        Decumbin
    Biological descriptionReversible inhibitor of protein translocation from the endoplasmic reticulum to the Golgi apparatus. Inhibits binding of the cytosolic coat protein, β-COP and ADP-ribosylation factor (ARF) to Golgi membranes and inhibits GDP-GTP exchange.
    Purity> 99%

• Molecular formulaC₁₆H₂₄O₄
• CAS Number20350-15-6
• PubChem identifier5287620
• Solubility overviewSoluble in DMSO to 50 mM

This product has been referenced in:

• Lippincott-Schwartz J  et al. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67:601-16 (1991). Read more (PubMed: 1682055) »
• Donaldson JG  et al. Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus. J Cell Biol 112:579-88 (1991). Read more (PubMed: 1993732) »
• Pelham HR Multiple targets for brefeldin A. Cell 67:449-51 (1991). Read more (PubMed: 1934055) »