Anti-Human CD338 (ABCG2) PE   12-8888-41

Also known as: Bcrp1, MXR
Clone: 5D3
RUO: For Research Use Only. Not for use in diagnostic procedures.
Host     Mouse
Isotype     IgG2b, kappa
Reactivity     Human
Conjugate     PE
Laser     Blue Laser, Green Laser, Yellow-Green Laser
Excite     488 - 561 nm
Reported Applications     Flow Cytometric Analysis

References: Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE. Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Res. 2012 Jul 15;72(14):3642-51. (5G3,FCPubMed)

Kim M, Turnquist H, Jackson J, Sgagias M, Yan Y, Gong M, Dean M, Sharp JG, Cowan K. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res. 2002 Jan;8(1):22-8.

Scharenberg CW, Harkey MA, Torok-Storb B.. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hemtopoietic progenitors. Blood. 2002 Jan 15;99(2):507-12.

Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med. 2001 Sep;7(9):1028-34.

Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med. 1997 Dec;3(12):1337-45.